Although it is a dietary supplement, milk thistle can theoretically interact with medications. Milk Thistle received an overall rating of 0 out of 10 stars from 0 reviews. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. A.D.A.M. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Milk thistle is a plant that is native to Europe and was brought to North America by early colonists. Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Coumadin, Jantoven) and others. Therefore, before using this product, tell your doctor or pharmacist of all the products you … It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Other less common side effects are nausea, diarrhea, indigestion, … They may decide to adjust your warfarin dose … Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Milk thistle can also produce estrogenic effects, so those who suffer from endometriosis or uterine fibroids should avoid milk thistle because of the possible contraindication. If you are taking any medications, speak with your health care provider to prevent any milk thistle interactions … Milk thistle is a herbal product widely used in the United States and around the world. How the interaction occurs: Milk thistle may slow down how quickly your body processes warfarin. However, little conclusive information is available about milk thistle interactions. Milk thistle might decrease hormones in the body. Common interactions include fall among females and fatigue among males. Possible interactions include: 1. Published February 24 2014. See what others have said about Milk Thistle, including the effectiveness, ease of use and side effects. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. /publications/issue/2015/September2015/Milk-Thistle-Drug-Interactions, Copyright Specialty Pharmacy Times 2006-2019, 2 Clarke Drive Suite 100 Cranbury, NJ 08512 P:609-716-7777 F:609-716-9038. Milk thistle and compounds derived from it are commonly used as herbal supplements for liver problems, but study results are mixed. Milk thistle extract is LIKELY SAFE when taken by mouth for most adults. Early research suggests that milk thistle … Expert panelists review the causes, diagnostic work-up, management, and emerging therapies inherent in the evolving paradigm of irritable bowel syndrome. One reported effect of milk thistle is that it can boost breast … 2. The American Journal of Pharmacy Benefits. Evidence, mechanism, importance and management. Closely monitor your blood sugar levels. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Milk thistle can change the way that your body metabolizes certain drugs in the liver, triggering interactions with: Antibiotics like Biaxin (clarithromycin) Anticoagulants like Coumadin … Diabetes Home > Milk Thistle Drug Interactions Although it is a dietary supplement , milk thistle can theoretically interact with medications. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. Milk thistle may interact with other drugs. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Milk thistle is one of the more popular herbs, as it is well known for its role in liver health. Laboratory studies suggest that milk thistle or some of its … Drug interactions are reported among people who take Xarelto and Milk thistle. Rate your experience with MILK THISTLE on WebMD including its effectiveness, uses, side effects, interactions, safety and satisfaction. A … Below is a short list of some … Talk to your doctor: Milk thistle does interact with warfarin & therefore should not be taken until you discuss with your primary medical provider or specialist. Common side effects may include: indigestion, bloating, gas, stomach pain; diarrhea; or nausea, loss of appetite. Taking milk thistle with diabetes drugs might cause additive effects. The study is created by eHealthMe based on … Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Han YU, Guo D, Chen Y, et al. Milk thistle might help the body break down estrogen pills to get rid of them. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. © 1997-. 3. Herb / drug interactions: The breakdown of milk thistle by certain liver enzymes may interfere with the action of drugs that are metabolized by those same enzymes. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs-- such as fexofenadine … Reduce the typical dose if you’re worried about a potential interaction with your statin drug. A Warning About Milk Thistle and Drug Interactions. Early research suggests that milk thistle … Wu J-W, Lin L-C, Tsai T-H. Drug–drug interactions of silymarin on the perspective of pharmacokinetics. Milk thistle can also change how your body metabolizes certain drugs, and while the drug interaction may not be harmful, milk thistle … Deng JW, Shon JH, Shin HJ, et al. Skip to content Check Your Symptoms Find A Doctor Find Lowest … USES: Milk thistle has been used for diabetes in combination with … Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle does not appear to affect the pharmacokinetics of irinotecan. Milk thistle sometimes causes a laxative effect. No interactions found. It Can Boost Breast Milk Production. Can any chemists or biologists let me know if it is safe to take effexor and milk thistle simultaneously? Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural product–drug interaction. Milk Thistle Drug Interactions. Some cellular studies found that milk thistle may affect CYP enzymes in the liver that metabolize drugs; … I read about an enzyme, CYP3A4, that is affected by milk thistle and Effexor is a substrate (not sure what that means) when broken down by the liver. John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD. It may lead to … Cytochrome P450 2C9 (CYP2C9) substrates. This document does not contain all possible interactions. Similarly, the fact that milk thistle … Compounds found in milk thistle -- sylibin, sylimarin … Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, … Metronidazole (Flagyl). Diabetes medications. Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. 30 July 2001. Milk Thistle Drug Interactions. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and … Milk thistle might lower blood sugar in people who have type 2 diabetes. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. However, little conclusive information is available about milk thistle interactions. Milk thistle may interact with some medications, including allergy medicines, anti-anxiety drugs and blood thinners, among others. The active complex of milk thistle is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin .In this article I will discuss some of the benefits of milk thistle… Common interactions include insomnia among females and fatigue among males. James F. Balch and Mark Stengler, authors of “Prescription for Natural Cures,” say that milk thistle is beneficial … Estrogens interacts with MILK THISTLE. Please indicate in layman's terms what occurs when a drug like Effexor is broken down in one's liver and the impact milk thistle … The study is created by eHealthMe based … Milk Thistle; Silybum marianum; St. Mary's Thistle. Drug interactions are reported among people who take Milk thistle and Metformin. Review provided by VeriMed Healthcare Network. Milk thistle + Irinotecan. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Related: PK and drug interactions. 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